Fan, Huahao

Education background:

2006-2010, Undergraduate of Taishan University. 

Work experience:

2016-2017, Research associate of Beijing 302 Hospital. 
 2017-2019, Postdoctoral fellow of Tsinghua University.

Academic title:

Young member of the branch of Microbiology and immunology, Beijing Medical Association

Research areas:

Research area 1: Molecular mechanism of emerging infectious pathogens (Coronavirus) infection.

Research area 2: Phage basics and clinical application.

Honors and awards:

Outstanding Postdoctoral Reward of Tsinghua University and Peking University Life Science Joint Center

Research projects:

Novel regulation mechanisms on animal-human-animal cross-species transmission of dengue virus and Zika virus, Major National Research and Development Project.

Representative works:

1.     Maochen Li*, Fuxing Lou*, Huahao Fan^#. SARS-CoV-2 variants: a new challenge to convalescent serum and mRNA vaccine neutralization efficiency. Signal Transduction and Targeted Therapy. 2021 Apr 10;6(1):151. (Nature group journal, Top journal, IF=17.6)

2.     Pengfei Pei*, Hongbo Qin*, Jialin Chen, Fengli Wang, Chengzhi He, Shiting He, Bixia Hong, Ke Liu, Ren-zhong Qiao, Huahao Fan^#, Yi-gang Tong^#, Long Chen^#, Shi-Zhong Luo^#. Computational Design of Ultrashort Peptide Inhibitors of the Receptor Binding Domain (RBD) of the SARS-CoV-2 S protein. Briefings in Bioinformatics. 2021 accept (Top journal, IF=10.3)

3.     Huahao Fan*, Bixia Hong*, Yuqian Luo*, Qi Peng*, Liqin Wang, Xiangshu Jin, Yangzhen Chen, Yunjia Hu, Yi Shi, Tong Li, Hui Zhuang, Yi-Hua Zhou^#, Yigang Tong^#, Kuanhui Xiang^#. The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro. Signal Transduction and Targeted Therapy. 2020, 5(1):275. (Nature group journal,Cover Story, Top journal, IF=17.6）

4.     Shasha Li*, Wenli Liu*, Yangzhen Chen*, Liqin Wang*, Wenlin An, Xiaoping An, Lihua Song, Yigang Tong^#, Huahao Fan^#, Chenyang Lu^#. Cepharanthine shows anti-viral activities by modulating cellular stress responses triggered by a SARS-CoV-2 related coronavirus. Briefings in Bioinformatics. 2020. 22(2):1378-1386. (Top journal, IF=10.3)

5.     Huahao Fan*, Liqin Wang*, Wenli Liu*, Xiaoping An*, Zhendong Liu, Xiaoqi He, Lihua Song^#,Yigang Tong^#. Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus (2019-nCoV) related coronavirus model. Chinese Medical Journal 2020, 5;133(9):1051-1056. (ESI highly cited paper, citation>160)

6.     Lijun Sun*, Junfen Fan*, Huiru Gao, Liying Shan, Xue Li, Hui Zhuang, and Huahao Fan^#. Background End-stage Liver Diseases but not Pure HBV Infection Exacerbate Clinical Outcomes in Patients with Acute Hepatitis E. Clinical infectious diseases 2020, 70(12):2747-2748. (Top journal, IF=8.091)

7.     Yunjia Hu*, Meiqin Liu*, Hongbo Qin*, Haofeng Lin, Xiaoping An, Zhengli Shi, Lihua Song^#, Xinglou Yang^#, Huahao Fan^#, Yigang Tong^#. Artemether, artesunate, arteannuin B, echinatin, licochalcone B and andrographolide effectively inhibit SARS-CoV-2 and related viruses in vitro. Frontiers in Cellular and Infection Microbiology. 2021 accept(IF=5.114)

8.     Huahao Fan^*,#, Junfen Fan*, Suming Chen, Yangzhen Chen, Huiru Gao, Liying Shan Xue Li, Fengjun Gu, Hui Zhuang^#, Lijun Sun^#. Prognostic Significance of End-stage Liver Diseases, Respiratory Tract Infection and Chronic Kidney Diseases in Symptomatic Acute Hepatitis E. Frontiers in Cellular and Infection Microbiology. 2021;10:593674. (IF=5.114)

9.     Yunjia Hu*, Shanwei Tong*, Ping Li*, Xiaoping An, Lihua Song^#, Xinglou Yang^#, Huahao Fan^#, Yigang Tong^#. Characterization and Genome Sequence of a Genetically Unique Escherichia bacteriophage vB_EcoM_IME392. Archives of Virology. 2021 accept (IF=2.436)

10.  Pengjun Han, Yunjia Hu, Xiaoping An, Lihua Song^#, Huahao Fan^#, Yigang Tong^#. Biochemical and genomic characterization of a novel bacteriophage BUCT555 lysing Stenotrophomonas maltophilia. Virus Research. 2021 May 28;301:198465. (IF=3.227)

11.  Lijun Sun*, Lijun Shen*, Junfen Fan*, Fengjun Gu, Mei Hu, Yiran An, Qing Zhou, Huahao Fan^#, Jingfeng Bi^#. Clinical features of patients with coronavirus disease 2019 from a designated hospital in Beijing, China. Journal of Medical Virology. 2020, 92(10):2055-2066. (IF=2.083, citation>50)

12.  Shengdong Luo*, Shanshan Lu*, Huahao Fan*, Zhihui Sun, Yan Hu, Ruisheng Li, Xiaoping An, Vladimir N Uversky, Zeliang Chen^#, Yigang Tong^#, Lihua Song^#. he Coxiella burnetii QpH1 plasmid is a virulence factor for colonizing bone marrow-derived murine macrophages. Journal of Bacteriology. 2021 203(9):e00588-20. (IF=3.294)

13.  Huan Zhang*, Huanying Zheng*, Jinying Zhu*, Qiao Dong*, Jin Wang*, Huahao Fan*, Yangzhen Chen*, Xi Zhang, Xiaohu Han, Qianlin Li, Jiahai Lu^#, Yigang Tong^#, Zeliang Chen^#. The Ubiquitin-modified Proteome of SARS-CoV-2-infected Host Cells Reveals Insights into Virus-Host Interaction and Pathogenesis. Journal of Proteome Research. 2021 May 7;20(5):2224-2239. (IF=4.324)

14.  Yunjia Hu*, Shanwei Tong*, Ping Li*, Xiaoping An, Lihua Song^#, Huahao Fan^#, Yigang Tong^#. Characterization and Genome Sequence of a Genetically Unique Escherichia bacteriophage vB_EcoM_IME392. Archives of Virology. 2021, accept (IF=2.436)

15.  Wenjing Zhang*, Rongrong Zhang*, Yunjia Hu*, Yujie Liu, Liqin Wang, Xiaoping An, Lihua Song, Taoxing Shi^#, Huahao Fan^#,Yigang Tong^#, Hui Liu^#. Biological characteristics and genomic analysis of a Stenotrophomonas maltophilia phage vB_SmaS_BUCT548. Virus Genes. 2021, 57(2):205-216. (IF=2.211)

16.  Huahao Fan*, Luhua Qiao*, Kyung-Don Kang, Junfen Fan, Wensheng Wei, and Guangxiang Luo. Attachment and post-attachment receptors important for hepatitis C virus infection and cell-to-cell transmission. Journal of Virology 2017, 91(13):e00280-17. (Top journal, IF=4.767)

17.  Ali Zamani*, Huahao Fan*, and Guangxiang Luo. Identification of cellular genes and pathways important for tumorigenicity of hepatocellular carcinoma cell lines by proteomic profiling. Oncotarget 2017, 8(56):96171-96183. (IF=5.168)

18.  Chen Chen*,Huahao Fan*,Yong Huang,Fan Peng,Hang Fan, Shoujun Yuan, and Yigang Tong. Recombinant lysostaphin protects mice from methicillin-resistant Staphylococcus aureus pneumonia. Biomed Research International 2014; 602185. (IF=2.276)

19.  Huahao Fan, Hang Fan, Xiaoping An, Yong Huang, Zhiyi Zhang, Zhiqiang Mi, and Yigang Tong. Complete genome sequence of IME11, a new N4-like bacteriophage. Journal of Virology 2012, 86:13861-13861. (Top journal, IF=4.767)

20.  Huahao Fan, Yong Huang, Zhiqiang Mi, Xiuyun Yin, Lin Wang, Hang Fan, Zhiyi Zhang, Xiaoping An, Jiankui Chen, and Yigang Tong. Complete genome sequence of IME13, a Stenotrophomonas maltophilia bacteriophage with large burst size and unique plaque polymorphism. Journal of Virology 2012, 86:11392-11393. (Top journal, IF=4.767)

21.  Huahao Fan, Zhiqiang Mi, Junfen Fan, Yuhui Hua, Guangqian Pei, Wenhui Zhang, Bo Zhang, Chen Chen, Jianbin Li, Xiaona Wang, Xiaoping An, Lin Wang, Xiuyun Yin, Jiankui Chen, and Yigang Tong. A fast method for large-scale isolation of phages from hospital sewage using clinical drug-resistant Escherichia coli. African Journal of Biotechnology 2012; 11:6143-6148.

22.  Huahao Fan, and Yigang Tong. Potential dual-use of bacteriophage related technologies in bioterrorism and biodefense. Journal of Bioterrorism & Biodefense 2012; 3(3):1000121.

Admission requirements:

Highly motivated and kindhearted. Experiences with virology, cellular biology or bioinformatics is preferred, but not required. Excellent oral and written skills for research presentation are expected.