Song, Lihua

Education background:

2001-2006, PhD student of Academy of Military Medical Science. 
1997-2001, Bachelor student of University of Shandong University. 

Work experience:

2006-2010, Assistant professor of Beijing Institute of Microbiology and Epidemiology.

2008-2008, Preventive physician of United Nations Mission in Liberia.

2010-2013, Postdoctoral fellow of RML/NIAID/NIH, USA.

2013-2018, Associate professor of Beijing Institute of Microbiology and Epidemiology.

2019 to now, Professor of Beijing University of Chemical Technology.

Research areas:

Our research interests focus on the pathogenesis of importantly intracellular microorgani**s, including, but not limited to, coronavirus, bacteriophage, brucella, chlamydia and coxiella. We use a number of state-of-the-art technologies in synthetic biology, structural biology and bioinformatics to investigate the interactions between these microorgani**s and their respective hosts. Novel findings will be employed to devise new strategies for the prevention and control of important infectious diseases.

Honors and awards:

Awarded the United Nations Peace Medal in 2008.

Second Prize of National Technology Invention in 2013.

Second Prize of National Science and Technology Progress in 2016.

Research projects:

(1) Science and Technology Department of Inner Mongolia Autonomous Region. Precise diagnosis technology and diagnostic criteria for brucellosis patients. Duration: 2019/11-2022/10.

(2) National Natural Science Foundation of China (NSFC). Grant No. 3191101002. Risk Factors and Mechani**s of Ruminant Abortion Caused by Brucella. Duration 2020/7-2022/12.

(3) Beijing Science and Technology Major Project. Grant No. Z171100000417015. Chlamydia trachomatis pla**id pathogenesis. Duration: 2017/3-2019/2.

(4) National Natural Science Foundation of China (NSFC). Grant No. 31570177. Pathogenic mechani** of Chlamydia trachomatis pla**id encoding virulence factor Pgp4. Duration 2016/1-2019/12.

Representative works:

(1). Huahao Fan, Liqin Wang, Wenli Liu, Xiaoping An, Zhendong Liu, Xiaoqi He, Lihua Song, and Yigang Tong. Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus (2019-nCoV) related coronavirus model. Chin Med J (Engl), 2020.

(2). Tao Wang, Yonghui Yu, Xiaofei Liang, Shengdong Luo, Zemin He, Zhihui Sun, Yongqiang Jiang, Anders Omsland, Pei Zhou and Lihua Song. Lipid A has significance for optimal growth of Coxiella burnetii in macrophage-like THP-1 cells and to a lesser extent in axenic media and non-phagocytic cells. Frontiers in Cellular and Infection Microbiology, 2018, 8: 192. doi: 10.3389/fcimb.2018.00192

(3). Gail L. Sturdevant, Claire E. Couch, Heather S. Watkins, Linnell B. Randall, Jillian M. Ilgenfritz, Lihua Song, Timothy R. Southern, William M. Whitmire, Harlan D. Caldwell, Laszlo Kari. The developmentally regulated Chlamydia trachomatis gene chxR is not essential for in vitro or in vivo growth. Pathogens and Disease, 2017, 75(3).

(4). Le Feng, Xinxin Lu, Yonghui Yu, Tao Wang, Shengdong Luo, Zhihui Sun, Qing, Duan, Ningli Wang, Lihua Song. Survey, Culture, and Genome Analysis of Ocular Chlamydia trachomatis in Tibetan Boarding Primary Schools in Qinghai Province, China. Frontiers in Cellular and Infection Microbiology, 2017, 6: 207. doi: 10.3389/fcimb.2016.00207.

(5). Chunfu Yang, Tregei Starr, Lihua Song, John H. Carlson, Gail L. Sturdevant, Paul A. Beare, William M. Whitmire, Harlan D. Caldwell. Chlamydial lytic exit from host cells is pla**id regulated. mBio, 2015, 6(6): e01648-15. doi:10.1128/mBio.01648-15.

(6). Stephen F. Porcel, John H. Carlson, Daniel E. Sturdevant, Gail L. Sturdevant, Kishore Kanakabandi, Kimmo Virtaneva, Hannah Wilder, William M. Whitmire, Lihua Song, Harlan D. Caldwell. Transcriptional Profiling of Human Epithelial Cells Infected with Pla**id-Bearing and Pla**id-Deficient Chlamydia trachomatis. Infection and Immunity, 2015, 83(2): 534-543.

(7). Gail L. Sturdevant, John H. Carlson, William M. Whitmire, Bing Zhou, Lihua Song, and Harlan D. Caldwell. Infectivity of urogenital Chlamydia trachomatis pla**id-deficient, CT135-null, and double-deficient strains in female mice [J]. Pathogens and Disease, 2014, 71(1): 90-92.

(8). Lihua Song, John H. Carlson, Bing Zhou, Kimmo Virtaneva, William M. Whitmire, Gail L. Sturdevant, Stephen F. Porcella, Grant McClarty, and Harlan D. Caldwell. Pla**id-mediated transformation tropi** of chlamydial biovars [J]. Pathogens and Disease, 2014, 70(2): 189-193.

(9). Lihua Song, John H. Carlson, William M. Whitmire, Laszlo Kari, Kimmo Virtaneva, Daniel E. Sturdevant, Heather Watkins, Bing Zhou, Gail L. Sturdevant, Stephen F. Porcella, Grant McClarty, and Harlan D. Caldwell. Chlamydia trachomatis Pla**id-Encoded Pgp4 Is a Transcriptional Regulator of Virulence-Associated Genes [J]. Infection and Immunity, 2013, 81(3): 636-44. (commented)

(10). Lihua Song, Bing Zhou, Hong Zhu, and Qing Duan. Outdoor electric mosquito killing apparatuses for malaria control in a hyperendemic area [J]. Clinical Infectious Diseases, 2009, 49: 480.

Admission requirements: