Xin Su Ph.D. Professor of Biomedical Engineering Email: xinsu@mail.buct.edu.cn Office: 15 Beisanhuan East Road, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China |
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Research Interests:
Nucleic acids are not only the carriers of genomic information but also promising building blocks for constructing advanced nanomaterials. DNA nanotechnology utilizes the base-pairing language to construct nanostructures and to manipulate matters at nanoscale, which has been widely applied in nanomachines, gene editing, molecular computing, and targeted drug delivery. The programmable design of DNA nanostructures emerges as an adaptable tool to enhance the performance of single-molecule sensing and imaging. Single-molecule tools enable translating biorecognition events into electrical and optical signals at the single-molecule level. By integrating DNA nanotechnology and single-molecule analysis, we are able to design robust molecular systems for biosensors, drug delivery vehicles, as well as advanced synthetic biology tools.
Our research by its very nature is highly interdisciplinary, engaging students with a diverse background and providing a broad education.
1. Developing nontrivial dynamic DNA reaction networks for advanced biosensors and biomimetic systems.
2. Operating DNA nanomachines in living cells for targeted drug delivery, nano-vaccine and molecule imaging.
3. Utilizing total internal reflection fluorescence microscopy to study natural and artificial nanoparticles at single-molecule level.
Research Area
DNA nanotechnology, Analytical Chemistry, Synthetic Biology, Nano-Chemistry, Single-molecule instruments, Cell imaging.
Education
B.S., College of Chemistry, Nankai University
Ph.D., College of Chemistry and Molecular Engineering, Peking University
Professional Experience
2021-now, Professor, College of Life Science and Technology, Beijing University of Chemical Technology
2015-2020, Associate Professor, College of Life Science and Technology, Beijing University of Chemical Technology
2013-2015, Visiting Scholar, worked with Prof. Nils G. Walter, Department of Chemistry, University of Michigan Ann Arbor
Awards and Honors
Beijing University of Chemical Technology Hundred Young Faculty Program
Outstanding Young Faculty of Beijing
National Scholarship for Doctoral students
Representative Publication
1. Alexander Johnson-Buck#, Xin Su#, Maria D Giraldez, Meiping Zhao, Muneesh Tewari, Nils G. Walter*, Kinetic fingerprinting to identify and count single nucleic acids, Nature Biotechnology, 2015, 33, 730-732. (co-first author)
2. Yingnan Deng, Liang Ma, Qianqian Han, Changyuan Yu, Alexander Johnson-Buck,* and Xin Su*, DNA-Templated Timer Probes for Multiplexed Sensing, Nano Letters, 2020, 20, 2688-2694.
3. Congshan Wang, Yingjie Yu, Muhammad Irfan, Bolong Xu, Junjie Li, Linghao Zhang, Zhaohui Qin, Changyuan Yu, Huiyu Liu,* and Xin Su*, Rational Design of DNA Framework-Based Hybrid Nanomaterials for Anticancer Drug Delivery, Small, 2020, 202002578.
4. Shengnan Fu, Na Li, Junjie Li, Yingnan Deng, Lida Xu, Changyuan Yu,* Xin Su*, Engineering High-Robustness DNA Molecular Circuits by Utilizing Nucleases, Nanoscale, 2020, 12, 6964-6970.
5. Shuang Cai, Yingnan Deng, Shengnan Fu, Junjie Li, Changyuan Yu, Xin Su*, Single-Molecule Dynamic DNA Junctions for Engineering Robust Molecular Switches, Chemical Science, 2019, 10, 9922-9927.
6. Yi Zhang, Yingnan Deng, Congshan Wang, Lidan Li, Lida Xu, Yingjie Yu*, Xin Su*, Probing and Regulating the Activity of Cellular Enzyme by DNA Tetrahedron Nanostructures, Chemical Science, 2019, 10, 5959-5966.
7. Lina Li, Yingjie Yu, Congshan Wang, Qianqian Han, Xin Su*, Transient Hybridization Directed Nanoflare for Single-Molecule miRNA Imaging, Analytical Chemistry, 2019, 91, 1112211128.
8. Zehao Li, Xu Zhou, Lidan Li, Shue, Liu, Congshan, Wang, Lina, Li, Changyuan, Yu*, Xin Su*; Probing DNA Hybridization Equilibrium by Cationic Conjugated Polymer for Highly Selective Detection and Imaging of Single-Nucleotide Mutation, Analytical Chemistry, 2018, 90, 6804-6810.
9. Yingjie Yu, Liang Ma, Lidan Li, Yingnan Deng, Lidan Xu, Hua Liu, Lehui Xiao*, Xin Su*, Digestion of Dynamic Substrate by Exonuclease Reveals High Single-Mismatch Selectivity, Analytical Chemistry, 2018, 90, 13655-13662.
10. Yingjie Yu, Tongbo Wu, Alexander Johnson-Buck, Lidan Li, Xin Su*, A two-layer assay for single-nucleotide variants utilizing strand displacement and selective digestion, Biosensors & Bioelectronics, 2016, 82, 248-254.