Name：Yushan Zhu Title： Professor, PhD Supervisor E-mail：zhuys@mail.buct.edu.cn Address： East Campus, Computer Building (West), Room 408 (O), Room 410 (L) College of Life Science and Technology Beijing University of Chemical Technology Beijing 100029, China |
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Education background:
1993，Tianjin University, Chemical Engineering, BE
1996，Tianjin University, Chemical Engineering, ME
1999，Chinese Academy of Sciences, Chemical Engineering, PhD
Work experience:
2021-Present，College of Life Science and Technology, Beijing University of Chemical Technology, Professor
2004-2020, Department of Chemical Engineering, Tsinghua University, Associate Professor
2001-2003，University of Tsukuba, Japan, JSPS Postdoctoral Fellow
Research Interest:
Our laboratory is focused on computational enzyme design, enzymatic catalysis, biochemical engineering, and synthetic biology. We have independently developed the computational enzyme design platform PRODA, and new enzymes can be constructed for the non-natural substrates and non-natural reactions combined with protein structure prediction, QM/MM calculation, molecular dynamics simulation, machine learning, and low-throughput experiments. PRODA can be used to facilitate the realization of biological synthesis of molecules in chemical, energy, material, environment, pharmaceutical, and food industries.
Selected Publications (Enzyme related only):
[10] P Wang, S Zhang, J Zhang, Y Zhu*. Computational design of penicillin acylase variants with improved kinetic selectivity for the enzyme synthesis of cefazolin. Biochemical Engineering Journal. 2021, 175: 108149.
[9] J Xue, P Wang, J Kuang, Y Zhu*. Computational design of new enzymes for hydrolysis and synthesis of third-generation cephalosporin antibiotics. Enzyme and Microbial Technology. 2020, 140: 109649.
[8] S Zhang, J Zhang, Y Zhu*. ProdaMatch: A fast and accurate active site matching algorithm for de novo enzyme design. Computers and Chemical Engineering. 2020, 140: 106921.
[7] M Lin, F Wang, Y Zhu*. Modeled structure-based computational redesign of a glycosyltransferase for the synthesis of rebaudioside D from rebaudioside A. Biochemical Engineering Journal. 2020, 159: 107626.
[6] J He, X Huang, J Xue, Y Zhu*. Computational redesign of penicillin acylase for cephradine synthesis with high kinetic selectivity. Green Chemistry. 2018, 20: 5484.
[5] Z Xu, Y Tian, Y Zhu*. Computational design of thermostable mutants for cephalosporin C acylase from Pseudomonas strain SE83. Computers and Chemical Engineering. 2018, 116: 112.
[4] X Huang, J Xue, M Lin, Y Zhu*. Computational design of cephradine synthase in a new scaffold identified from structural databases. Chemical Communications. 2017, 53: 7604.
[3] Y Tian, X Huang, Q Li, Y Zhu*. Computational design of variants of cephalosporin C acylase from Pseudomonas strain N176 with improved stability and activity. Applied Microbiology and Biotechnology. 2017, 101: 621.
[2] X Huang, K Han, Y Zhu*. Systematic optimization model and algorithm for binding sequence selection in computational enzyme design. Protein Science. 2013, 22: 929.
[1] Y Lei, W Luo, Y Zhu*. A matching algorithm for catalytic residue site selection in computational enzyme design. Protein Science. 2011, 20：1566.
教师寄语
持之以恒、坚持不懈。
招生要求
欢迎生物、化学、工程及计算机科学等背景（不限）的学生加入实验室，以科研助理、博士后、博士生、硕士生或本科生等进行科研工作。咨询请发送邮件到：zhuys@mail.buct.edu.cn。