Name：Zhao Yang Title：Associate Professor E-mail：yangzhao@mail.buct.edu.cn Address：B312, Huaxin Building |
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Education background:
2010.9-2015.6 CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Ph.D, Major in Biochemistry and Molecular Biology
2006.9-2010.6 College of Life Science, Jilin University, Bachelor of Science, Major in Biology & Chemistry
Work experience :
2018.9 to now, College of Life Science and Technology, Beijing University of Chemical Technology, Associate Professor
2015.7-2018.8 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Assistant Professor
Academic title:
1) Associate Editor-in-Chief of Cancer +（http://www.cancer.whioce.com/index.php/cancer）
2) Member of the Youth Work Committee of the Chinese Society of Biotechnology
3) Standing Committee Member of Beijing Research Society for Precise Pathological Diagnosis of Neopla**
Research areas:
1) Biomarkers and antibody drugs of cancer
2) Cancer stem cells
3) Cancer immunotherapy
Honors and awards:
Research projects:
1) Prevention and resolution of major risks in advanced biotechnology. Major Program of the National Social Science Fund of China (Co-Investigator)
2) Visual Stem Cell Targeted Tumor Therapy for Tumor Precise Diagnosis and Treatment. Beijing-Tianjin-Hebei Basic Research Cooperation Special Project (Principal Investigator of Sub-project)
3) Structure and function of a new CRISPR-Cas12a system. The Basic Scientific Research Operating Expenses for Central Universities (Principal Investigator)
4) The mutation characteristics and evolution of bladder urothelial stem cells. National Key Research and Development Program (Co-Investigator)
5) The screen of KMT1A inhibitors and its suppressing mechani**s to bladder cancer stem cells. Youth Program of National Natural Science Foundation of China (Principal Investigator)
6) The self-renewal mechani**s of bladder cancer stem cells mediated by long non-coding RNA lncAC1. National Natural Science Foundation of China (General Program) (Co-Investigator)
7) The self-renewal mechani**s of bladder cancer stem cells regulated by Hedgehog signaling activated by GALNT1.Key Program of National Natural Science Foundation of China (Key Program) (Co-Investigator)
Representative works:
[1] Zhao Yang# , Kun Zhang, Tianying Xing, Suhang Bai, Zongyi Shen, Luyao Wang, Lingzhi Wan, Zichen Zhang, Chong Li, Wei Zhang. Application of Clustered Regularly Interspaced Short Palindromic Repeat-Cas12a System in Cancer Research and its Structural Basis. Cancer+. (2019) 1(3):1–6
[2] Zhao Yang# , Haifeng Wang#, Suhang Bai, Zongyi Shen, Bo Zhong, Qiuyun Yan, Dongxiao Cheng, Wei Zhang, Jian Zhuang , Lingzhi Wang, Xinlu Yu, Fuhan Zhang, Ruonan Gao, Yuhan Yan , Changyuan Yu, Chong Li. LncRNA and gene expression profiling of human bladder cancer. Cancer+. (2019) 1(1):1-7
[3] Zongyi Shen, Maochen Li, Suhang Bai, Qingkun Yang, Fuhan Zhang, Mao Tang, Jiangyu Guo, Zhao Yang. Advances in liver cancer immunotherapy. Chinese Journal of Biotechnology, 2019,35(12):2326-2338.
[4] Suhang Bai, Xiaoyue Yang, Nan Zhang, Fuhan Zhang, Zongyi Shen,Na Yang, Wensai Zhang, Changyuan Yu, Zhao Yang. Research progress on the role of tumor infiltrating lymphocytes in solid tumors. Chinese Journal of Biotechnology, 2019,35(12):2308-2325.
[5] Hongwei Su#, Tao Tao#, Zhao Yang#, Xing Kang, Xu Zhang, Danyue Kang, Song Wu and Chong Li. Circular RNA cTFRC acts as the sponge of MicroRNA-107 to promote bladder carcinoma progression. Mol Cancer. 2019,19;18(1):27.
[6] Zhao Yang#, Ruiyun Zhang#, Yunxia Ge, Xuying Qin, Xing Kang, Yue Wang, Xu Zhang, Chengli Song, Xiaofang Quan, Haifeng Wang, Haige Chen and Chong Li. Somatic FGFR3 Mutations Distinguish a Subgroup of Muscle-Invasive Bladder Cancers with Response to Neoadjuvant Chemotherapy. EBioMedicine. 2018, 35:198-203.
[7] Zhao Yang, Luyun He, Kaisu Lin, Yun Zhang, Aihua Deng, Yong Liang, Chong Li and Tingyi Wen. The KMT1A-GATA3-STAT3 circuit is a novel self-renewal signaling of human bladder cancer stem cells. Clin Cancer Res. 2017, 1;23(21):6673-6685.
[8] Chong Li#, Song Wu#, Zhao Yang#, Xiaolong Zhang#, Qi Zheng, Ling Lin, Zexiong Niu, Ruiqiang Li, Zhiming Cai, Lei Li. Single-cell exome sequencing identifies KCP, LOC440040, and LOC440563 as driver genes in renal cell carcinoma stem cells. Cell Res. 2017, 27(4):590-593.
[9] Zhao Yang#, Chong Li#, Zusen Fan#, Hongjie Liu#, Xiaolong Zhang#, Zhiming Cai#,Liqin Xu, Jian Luo, Yi Huang, Luyun He, Chunxiao Liu and Song Wu. Single-cell sequencing reveals variants in ARID1A, GPRC5A and MLL2 driving self-renewal of human bladder cancer stem cells. Eur Urol. 2017,71(1):8-12.
[10] Chong Li#, Song Wu#, Zhao Yang#, Xiaolong Zhang#, Qi Zheng, Ling Lin, Zexiong Niu, Ruiqiang Li, Zhiming Cai, Lei Li. Single-cell exome sequencing identifies mutations in KCP, LOC440040, and LOC440563 as drivers in renal cell carcinoma stem cells. Cell Res. (2017) 27:590-593.
[11] Zhao Yang#, Shengwu Liu#, Mingao Zhu, Hong Zhang, Ji Wang, Qian Xu, Kaisu Lin, Xiumin Zhou, Min Tao, Chong Li and Hong Zhu. PS341 inhibits hepatocellular and colorectal cancer cells through the FOXO3/CTNNB1 signaling pathway. Sci Rep. 2016, 26;6:22090.
[12] Chong Li#, Ying Du#, Zhao Yang#, Luyun He, Yanying Wang, Lu Hao, Mingxia Ding,
Ruping Yan, Jiansong Wang, and Zusen Fan. GALNT1-Mediated Glycosylation and Activation of Sonic Hedgehog Signaling Maintains the Self-Renewal and Tumor-Initiating Capacity of Bladder Cancer Stem Cells. Cancer Res. 2016, 1;76(5):1273-83.
[13] Buqing Ye#, Chong Li#, Zhao Yang#, Yanying Wang, Junfeng Hao, Li Wang, Yi Li, Ying Du, Lu Hao, Benyu Liu, Shuo Wang, Pengyan Xia, Guanling Huang, Lei Sun, Yong Tian and Zusen Fan. Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation. J Exp Med. 2014, 17;211(12):2439-54.
Selected monographs:
1) Antibody factory, Tianjin Science and Technology Press, June 2018
2) Non-coding RNA and tumor, Tianjin Science and Technology Press, June 2018
3) Cell signaling pathway, Tianjin Science and Technology Press, June 2018
4) Essentials of Tumor-Related Genes, Tianjin Science and Technology Press, August 2017
5) Collection of basic and translational medical research papers on bladder cancer, Tianjin Science and Technology Press, August 2017
Admission requirements:
Be optimistic and pragmatic.
Be good at thinking, communication and cooperation.
Have strong interest in scientific research and strong executive force.