Address：Room W414, Building of Science and Technology, Beijing University of Chemical Technology
2000-2004 B.S. Beijing University of Chemical Technology
2004-2010 Ph.D. Beijing University of Chemical Technology
Work experience :
2010-2012 Postdoctoral Researcher, Beijing University of Chemical Technology
2014-2015 Visiting Professor, Georgia Institute of Technology
2012-now Associate Professor, College of Life Science and Technology, Beijing University of Chemical Technology.
Reviewer for J. Med. Chem., Adv. Synth. Catal., Bioconjugate Chem., et. al.
Member of Western Returned Scholars Association of P.R.China
Associate editor of Chem. Res.
Our laboratory research addresses a wide range of fundamental problems at the interface of organic chemistry and biology. My research seeks to discover and construct compounds with incredibly diverse properties and applications ranging from artificial nucleases as potential molecular biology tools to general interaction with biomacromolecules (DNA & protein), including molecular recognition and cleavage of DNA, design and evaluation of non-viral gene vector, synthesis and test of anti-HIV polymeric prodrug, investigation of reversible DNA condensing process, and even DNA-based hybrid catalyst.
Honors and awards:
DuPont Scholarship (2010)
Co-host in the National Nature Science Foundation of China (NSFC) (2020-2023)
Host in the National Nature Science Foundation of China (NSFC) (2016-2019)
Title:Design of Hybrid Chiral Catalysts Based on Self-assembly and Evaluation of Asymmetric reaction
Host in the National Nature Science Foundation of China (NSFC) (2013-2015)
Title: Design, mechani** and biological evaluation of the novel controllable DNA condensed agents
1. J. K. Bai, X. L. Sun, H. S. Wang, C. Li*, R. Z. Qiao*.Guanosine-Based Self-Assembly as an Enantioselective Catalyst Scaffold. J. Org. Chem. 2020, doi.org/10.1021/acs.joc.9b02718.
2. M. Y. Zhu, H. Zhou, D. D. Ji, G. Li, F. Wang, D. Y. Song, B. Deng, C. Li*, R. Z. Qiao*. A near-infrared fluorescence probe for ultrafast and selective detection of peroxynitrite with large Stokes shift in inflamed mouse models. Dyes and Pigments, 2019, 168, 77-83.
3. Y. L. Ju, J. T. Wu, X. Yuan, L. Q. Zhao, G. L. Zhang, C. Li*, R. Z. Qiao*. Design and Evaluation of Potent EGFR Inhibitors through the Incorporation of Macrocyclic Polyamine Moieties into the 4-Anilinoquinazoline Scaffold. J. Med. Chem. 2018, 61, 11372-11383.
4. H. Zhou, D. Chen, J. K. Bai, X. L. Sun, C. Li*, R. Z. Qiao*. Effect of ligand sequence-specific modification on DNA hybrid catalysis. Org. Biomol. Chem. 2017, 15, 6738-6745. (cover paper)
5. Chunying Ma, Xiao Zhang, Changguo Du, Baojing Zhao, Chunhua He, Chao Li*, and Renzhong Qiao. Water-soluble Cationic Polyphosphazenes Grafted with Cyclic Polyamine and Imidazole as An Effective Gene Delivery Vector. Bioconjugate Chem. 2016, 27, 1005-1012.
Optimistic, diligent and positive