Li, Chao

Date:2020-04-11

NameChao Li

TitleAssociate Professor

E-maillichao@mail.buct.edu.cn

AddressRoom W414,   Building of Science and Technology, Beijing University of Chemical Technology



Education background:

2000-2004    B.S. Beijing University of Chemical Technology

2004-2010    Ph.D. Beijing University of Chemical Technology


Work experience :

2010-2012    Postdoctoral Researcher, Beijing University of Chemical Technology

2014-2015   Visiting Professor, Georgia Institute of Technology

2012-now     Associate Professor, College of Life Science and Technology, Beijing University of Chemical Technology.


Academic title:

Reviewer for J. Med. Chem., Adv. Synth. Catal., Bioconjugate Chem., et. al.

Member of Western Returned Scholars Association of P.R.China

Associate editor of Chem. Res.


Research areas:

Our laboratory research addresses a wide range of fundamental problems at the interface of organic chemistry and biology. My research seeks to discover and construct compounds with incredibly diverse properties and applications ranging from artificial nucleases as potential molecular biology tools to general interaction with biomacromolecules (DNA & protein), including molecular recognition and cleavage of DNA, design and evaluation of non-viral gene vector, synthesis and test of anti-HIV polymeric prodrug, investigation of reversible DNA condensing process, and even DNA-based hybrid catalyst.


Honors and awards:

DuPont Scholarship (2010)


Research projects:

Co-host in the National Nature Science Foundation of China (NSFC) (2020-2023)

Host in the National Nature Science Foundation of China (NSFC) (2016-2019)

Title:Design of Hybrid Chiral Catalysts Based on Self-assembly and Evaluation of Asymmetric reaction

Host in the National Nature Science Foundation of China (NSFC) (2013-2015)

Title: Design, mechani** and biological evaluation of the novel controllable DNA condensed agents


Representative works:

1. J. K. Bai, X. L. Sun, H. S. Wang, C. Li*, R. Z. Qiao*.Guanosine-Based Self-Assembly as an Enantioselective Catalyst Scaffold. J. Org. Chem. 2020, doi.org/10.1021/acs.joc.9b02718.

2. M. Y. Zhu, H. Zhou, D. D. Ji, G. Li, F. Wang, D. Y. Song, B. Deng, C. Li*, R. Z. Qiao*. A near-infrared fluorescence probe for ultrafast and selective detection of peroxynitrite with large Stokes shift in inflamed mouse models. Dyes and Pigments, 2019, 168, 77-83.

3. Y. L. Ju, J. T. Wu, X. Yuan, L. Q. Zhao, G. L. Zhang, C. Li*, R. Z. Qiao*. Design and Evaluation of Potent EGFR Inhibitors through the Incorporation of Macrocyclic Polyamine Moieties into the 4-Anilinoquinazoline Scaffold. J. Med. Chem. 2018, 61, 11372-11383.

4. H. Zhou, D. Chen, J. K. Bai, X. L. Sun, C. Li*, R. Z. Qiao*. Effect of ligand sequence-specific modification on DNA hybrid catalysis. Org. Biomol. Chem. 2017, 15, 6738-6745. (cover paper)

5. Chunying Ma, Xiao Zhang, Changguo Du, Baojing Zhao, Chunhua He, Chao Li*, and Renzhong Qiao. Water-soluble Cationic Polyphosphazenes Grafted with Cyclic Polyamine and Imidazole as An Effective Gene Delivery Vector. Bioconjugate Chem. 2016, 27, 1005-1012.


Admission requirements:

Optimistic, diligent and positive