Name:Aili Fan Title:Dr. E-mail:f****@mail.buct.edu.cn Address:North Third Ring Road 15, Chaoyang District, Beijing 100029, China |
|
Education background:
2005-2011, Undergraduate and Master student of Peking University, China.
2011-2015, PhD student of Philipps-Universität Marburg, Germany.
Work experience:
2015-2017, Research Associate of Institute of Microbiology, Chinese Academy of Science.
2017 to now, Associate Professor of Beijing University of Chemical Technology.
Academic title:
Research areas:
1. Biosynthetic study of bioactive fungal secondary metabolites and functional study of key enzyme in the biosynthetic pathway
2. Plastic biodegradation and upcycling
Honors and awards:
Research projects:
1. National Key R&D Program of China (2018YFA0902200)
2. The National Natural Science Foundation of China (81803409, 21838001, and 31961133017)
3. The Fundamental Research Funds for the Central Universities (grant numbers buctrc201810 and XK1802-8)
Representative works:
[1] Li, W. #, Fan, A.(Fan, Aili)#, Wang, L., Zhang, P., Liu, Z., An, Z., Yin, W.-B. (2018) Asperphenamate biosynthesis reveals a novel two-module NRPS system to synthesize amino acid esters in fungi. Chem. Sci. 9, 2589-2594. (# contribute equally)
[2] Fan, A.#, Mi, W. #, Liu, Z., Zeng, G., Zhang, P., Hu, Y., Fang, W., Yin, W.-B. (2017) Deletion of a histone acetyltransferase leads to the pleiotropic activation of natural products in Metarhizium robertsii. Org. Lett. 19,1686-1689.
[3] Fan, A. and Li, S.-M. (2016) Saturation mutagenesis on Arg244 of the tryptophan C4-prenyltransferase FgaPT2 leads to enhanced catalytic ability and different preferences for tryptophan-containing cyclic dipeptides. Appl. Microbiol. Biotechnol. 100, 5389-5399.
[4] Fan, A. and Li, S.-M. (2013). One substrate - seven products with different prenylation positions in one-step reactions: prenyltransferases make it possible. Adv. Synth. Catal. 355, 2659-2666.
[5] Fan, A., Zocher, G., Stec, E., Stehle, T., and Li, S.-M. (2015). Site-directed mutagenesis switching a dimethylallyl tryptophan synthase to a specific tyrosine C3-prenylating enzyme. J. Biol. Chem. 290, 1364-1373.
[6] Fan, A., Winkelblech, J. and Li, S.-M. (2015). Impacts and perspectives of prenyltransferases of the DMATS superfamily for use in biotechnology. Appl. Microbiol. Biotechnol. 99, 7399-7415. (invited review).
[7] Fan, A., Xie, X. and Li, S.-M. (2015). Tryptophan prenyltransferases showing higher catalytic activities for Friedel-Crafts alkylation of o- and m-tyrosine than tyrosine prenyltransferases. Org. & Biomol. Chem. 13, 7551-7557.
[8] Fan, A. and Li, S.-M. (2014). Prenylation of tyrosine and derivatives by a tryptophan C7-prenyltransferase. Tetrahedron Lett. 55, 5199-5202.
[9] Fan, A., Chen, H., Wu, R., Xu, H., and Li, S.-M. (2014). A new member of the DMATS superfamily from Aspergillus niger catalyzes prenylations of both tyrosine and tryptophan derivatives. Appl. Microbiol. Biotechnol. 98, 10119-10129.
[10] Fan, A., Lin, W., and Jia, Y. (2011) Recent research progress in the research on lamellarins and related pyrrole-derived alkaloids from marine organi**s. J. Chin. Pharm. Sci. 20, 425–441. (Invited review)
Admission requirements: