Fan, Aili

Date:2020-04-11

NameAili Fan

TitleDr.

E-mailf****@mail.buct.edu.cn

AddressNorth Third Ring Road 15, Chaoyang District,   Beijing 100029, China

  



Education background:

2005-2011, Undergraduate and Master student of Peking University, China. 
2011-2015, PhD student of Philipps-Universität Marburg, Germany. 


Work experience:

2015-2017, Research Associate of Institute of Microbiology, Chinese Academy of Science. 
2017 to now, Associate Professor of Beijing University of Chemical Technology. 


Academic title:


Research areas:

1. Biosynthetic study of bioactive fungal secondary metabolites and functional study of key enzyme in the biosynthetic pathway

2. Plastic biodegradation and upcycling

  


Honors and awards:


Research projects:

1. National Key R&D Program of China (2018YFA0902200)

2. The National Natural Science Foundation of China (81803409, 21838001, and 31961133017)

3. The Fundamental Research Funds for the Central Universities (grant numbers buctrc201810 and XK1802-8)


Representative works:

[1] Li, W. #, Fan, A.(Fan, Aili)#, Wang, L., Zhang, P., Liu, Z., An, Z., Yin, W.-B. (2018) Asperphenamate biosynthesis reveals a novel two-module NRPS system to synthesize amino acid esters in fungi. Chem. Sci. 9, 2589-2594. (# contribute equally)

[2] Fan, A.#, Mi, W. #, Liu, Z., Zeng, G., Zhang, P., Hu, Y., Fang, W., Yin, W.-B. (2017) Deletion of a histone acetyltransferase leads to the pleiotropic activation of natural products in Metarhizium robertsii. Org. Lett. 19,1686-1689. 

[3] Fan, A. and Li, S.-M. (2016) Saturation mutagenesis on Arg244 of the tryptophan C4-prenyltransferase FgaPT2 leads to enhanced catalytic ability and different preferences for tryptophan-containing cyclic dipeptides. Appl. Microbiol. Biotechnol. 100, 5389-5399.

[4] Fan, A. and Li, S.-M. (2013). One substrate - seven products with different prenylation positions in one-step reactions: prenyltransferases make it possible. Adv. Synth. Catal. 355, 2659-2666.

[5] Fan, A., Zocher, G., Stec, E., Stehle, T., and Li, S.-M. (2015). Site-directed mutagenesis switching a dimethylallyl tryptophan synthase to a specific tyrosine C3-prenylating enzyme. J. Biol. Chem. 290, 1364-1373.

[6] Fan, A., Winkelblech, J. and Li, S.-M. (2015). Impacts and perspectives of prenyltransferases of the DMATS superfamily for use in biotechnology. Appl. Microbiol. Biotechnol. 99, 7399-7415. (invited review).

[7] Fan, A., Xie, X. and Li, S.-M. (2015). Tryptophan prenyltransferases showing higher catalytic activities for Friedel-Crafts alkylation of o- and m-tyrosine than tyrosine prenyltransferases. Org. & Biomol. Chem. 13, 7551-7557.

[8] Fan, A. and Li, S.-M. (2014). Prenylation of tyrosine and derivatives by a tryptophan C7-prenyltransferase. Tetrahedron Lett. 55, 5199-5202.

[9] Fan, A., Chen, H., Wu, R., Xu, H., and Li, S.-M. (2014). A new member of the DMATS superfamily from Aspergillus niger catalyzes prenylations of both tyrosine and tryptophan derivatives. Appl. Microbiol. Biotechnol. 98, 10119-10129.

[10] Fan, A., Lin, W., and Jia, Y. (2011) Recent research progress in the research on lamellarins and related pyrrole-derived alkaloids from marine organi**s. J. Chin. Pharm. Sci. 20, 425–441. (Invited review)


Admission requirements: