Liang, Hao


Hao Liang, Professor

Education Experience:

1998-2002,B.S. Beijing University of Chemical Technology

2002-2007,Ph.D. Beijing University of Chemical Technology

Professional experience:

2007-2010,Assistant Professor, College of Life Science and Technology, Beijing University of Chemical Technology

2011-2014,Associate Professor, College of Life Science and Technology, Beijing University of Chemical Technology

2014-2016,  Visiting Scholar, Institute of Nanotechnology, University of Waterloo

2014-now,Professor, College of Life Science and Technology, Beijing University of Chemical Technology

Research Interest:

  • Biocatalysis and Bionanotechnology

  • Research and Development of Natural Active Compounds

  • Separation and Purification Technology

Selected Publications:

  1. Junya Liao, Shanshan Han, Xianglai Li, Jie He, Francesco Secundo, Hao Liang*. Co-immobilization of two-component hydroxylase monooxygenase by functionalized magnetic nanoparticles for preserving high catalytic activity and enhancing enzyme stabilty. International Journal of Biological Macromolecules. 2020, 164, 3163-3170.

  2. Qiao Wu, Huiling Gao, Frank Vriesekoop, Zexun Liu, Jie He, Hao Liang. Calcium Phosphate Coated Core-Shell Protein Nanocarriers: Robust Stability, Controlled Release and Enhanced Anticancer Activity for Curcumin Delivery. Journal: Materials Science & Engineering C. 115 (2020) 111094.

  3. Siqi Zhang, Xueqi Li,Qipeng Yuan,Francesco Secundo,Ye Li,Hao Liang. Step-wise immobilization of multi-enzyme by zirconium-based coordination polymer in situ self-assembly and specific absorption. Journal of Inorganic Biochemistry. Volume 208, July 2020, 111093.

  4. Amjad Hussain MemonRunsheng DingYi GuoFeibao TianJianhua HuZijian Yang & Hao Liang. Green Reclaiming of Riboflavin from Crystallization Mother Liquor by Macroporous Resin and Electrodialysis. Environment, Development and Sustainability, 2021, 23(3), 3114-3129

  5. Mengzhao Jiao, Zhengjun Li, Xianglai Li, Zijie Zhang, Qipeng Yuan, Frank Vriesekoop, Hao Liang*, and Juewen Liu*, Solving the H2O2 by-product problem using a catalase-mimicking nanozyme cascade to enhance glycolic acid oxidase. Chemical Engineering Journal. 2020, 388, 124249

  6. Liu, Zexun; Wu, Qiao; He, Jie; Vriesekoop, Frank; Liang, Hao. Crystal seeded growth of pH-responsive metal-organic framework for enhancing encapsulation, stability and bioactivity of hydrophobicity compounds. ACS Biomaterials Science & Engineering, 2019, 5, 12, 6581-6589

  7. Najaf Ali Soomro, Qiao Wu, Safdar Ali Amur, Hao Liang, Aziz Ur Rahman, Qeping Yuan, Yun Wei. Natural drug physcion encapsulated zeolitic imidazolate framework, and their application as antimicrobial agent. Colloids and Surfaces B: Biointerfaces 182 (2019) 110364

  8. J. He, S. Sun, M. Lu, Q. Yuan, Y. Liu and H. Liang, Metal-nucleobase hybrid nanoparticles for enhancing the activity and stability of metal-activated enzymes. Chem. Commun., 2019,  55, 6293 – 6296. DOI: 10.1039/C9CC03155C.

  9. Amjad Hussain Memon, Runsheng Ding, QipengYuan, Yun Wei, Hao Liang. Facile synthesis of alcalase-inorganic hybrid nanoflowers used for soy protein isolate hydrolysis to improve its functional properties. Food Chemistry. 2019, 289, 568-574.

  10. Jie He, Yumei Zhang, Qipeng Yuan, and Hao Liang* Catalytic Activity and Application of Immobilized Chloroperoxidase by Biometric Magnetic Nanoparticles. Ind. Eng. Chem. Res. 2019,  58, 8, 3555-3560

  11. Jie He, Shanshan Sun, Zhao Zhou, Qipeng Yuan, Yanhui Liu and Hao Liang*. Thermostable enzyme-immobilized magnetic responsive Ni-based metal-organic framework nanorods as recyclable biocatalysts for efficient biosynthesis of S-adenosylmethionine. Dalton Transactions 2019,48, 2077-2085. 

  12. Amjad Hussain Memon1, Runsheng Ding1, Qipeng Yuan, Hao Liang, Yun Wei. Coordination of GMP ligand with Cu to enhance the multiple enzymes stability and substrate specificity by co-immobilization process. Biochemical Engineering Journal. 2018, 136, 102-108. (IF:3.226)

  13. Hao Liang*, Yongqin Wei, Ruimin LiLi ChengQipeng YuanFuping Zheng. Intensifying sulforaphane formation in broccoli sprouts by using other cruciferous sprouts additions [J]. Food Science and Biotechnology. 2018,27(4), 957-962. (IF:0.786)

  14. Yan Zhou†, Shanshan Sun†, Weiya Bei, Mohamed Reda Zahi, Qipeng Yuan, Hao Liang*. Preparation and Antimicrobial Activity of Oregano essential oil Pickering emulsion stabilized by Cellulose nanocrystals [J]. International Journal of Biological Macromolecules, 2018, 112:7-13. (IF:3.671)

  15. Yongqin Wei, Frank Vriesekoop, Qipeng Yuan, and Hao Liang. β-Lactoglobulin as a Nanotransporter for Glabridin: Exploring the Binding Properties and Bioactivity Influences. ACS Omega 2018 3 (9), 12246-12252 DOI: 10.1021/acsomega.8b01576

  16. Liang, H.; Sun, S.; Zhou, Y.; Liu, Y. In-Situ Self-Assembly of Zinc/Adenine Hybrid Nanomaterials for Enzyme Immobilization. Catalysts 2017, 7, 327; doi:10.3390/catal7110327.

  17. Yongqin Wei , Jin ZhangAmjad Hussain MemonHao Liang. Molecular model and in vitro antioxidant activity of a water-soluble and stable phloretin/hydroxypropyl-β-cyclodextrin inclusion complex. Journal of Molecular Liquids, 2017, 236, 68-75.

  18. Yan Liu, Yumei Zhang, Xuejian Li, Qipeng Yuan and Hao Liang. Self-repairing metal-organic hybrid complexes for reinforcing immobilized chloroperoxidase reusability. Chem. Commun., 2017,53, 3216-3219.

  19. Chunfang Li, Shuhui Jiang, Xinying Zhaoand Hao Liang. Co-Immobilization of Enzymes and Magnetic Nanoparticles by Metal-Nucleotide HydrogelNanofibers for Improving Stability and Recycling. Molecules  2017, 22(1), 179; doi:10.3390/molecules22010179

  20. Hao Liang, Feifei Lin, Zijie Zhang, Biwu Liu, Shuhui Jiang, Qipeng Yuan, and Juewen Liu Multi-copper Laccase Mimicking Nanozymes with Nucleotides as Ligands. ACS Applied Materials & Interfaces, 2017, 9(2):1352-1360. 

  21. Yongqin Wei, Jin Zhang, Yan Zhou, Weiya Bei, Yuan Li, Qipeng Yuan, Hao Liang Characterization of Glabridin/hydroxypropyl-β-cyclodextrin Inclusion Complex with Robust Solubility and Enhanced Bioactivity. Carbohydrate Polymers. 2017, 159, 152-160.

  22. Mohamed Reda Zahi, Mohamed El Hatta, Hao Liang, Qipeng Yuan. Enhancing the antimicrobial activity of d-limonene nanoemulsion with the inclusion of ε-polylysine. Food Chemistry, 2017, 221 (15), 18-23.

  23. Ruimin Li, Dan Song, Frank Vriesekoop, Li Cheng, Qipeng Yuan and Hao Liang. Glucoraphenin, sulforaphene, and antiproliferative capacity of radish sprouts in germinating and thermal processes. European Food Research and Technology 2017, 243 (4), 547-554. 

  24. Xiao Zhou, Yan Liu, Qipeng Yuan, Hao Liang. Preparation of multi-enzyme co-immobilized nanoparticles by bis-aryl hydrazone bond conjugation. Biotechnology and Applied Biochemistry. 2016, 63 (2), 214-219. 

  25. Hao Liang*, Biwu Liu, Qipeng Yuan and Juewen Liu*, Magnetic Iron Oxide Nanoparticle Seeded Growth of Nucleotide Coordinated Polymers, ACS Applied Materials & Interfaces, 2016, 8 (24), pp 15615–15622. 

  26. Jing Sun, Dennis Curry, Qipeng Yuan, Xu Zhang, and Hao Liang. Highly Hybridizable Spherical Nucleic Acids by Tandem Glutathione Treatment and Polythymine Spacing. ACS Appl. Mater. Interfaces. 2016, 8 (19), pp 12504–12513.  

  27. Liang, H.; Jiang, S.; Yuan, Q.; Li, G.; Wang, F.; Zhang, Z.; Liu, J. Co-immobilization of multiple enzymes by metal coordinated nucleotide hydrogel nanofibers: improved stability and an enzyme cascade for glucose detection. Nanoscale 2016, 8, 6071–6078.  

  28. Miaomiao Li, Mohamed Reda Zahi, Qipeng Yuan, Feibao Tian, Hao Liang. Preparation and Stability of Astaxanthin Solid Lipid Nanoparticles Based on Stearic Acid. European Journal of Lipid Science and Technology, 2016, 118, 4, 592-602.

  29. Rong Shi, Qiuyue Zhang, Frank Vriesekoop, Qipeng Yuan, Hao Liang. Preparation of Organogel with Tea polyphenols Complex for Enhancing the Antioxidation Properties of Edible Oil. J. Agric. Food Chem., 2014, 62 (33), 8379–8384.  

  30. Chunxia Wen, Qipeng Yuan, Hao Liang, Frank Vriesekoop. Preparation and Stabilization of D-limonene Pickering Emulsions by Cellulose Nanocrystals. Carbohydrate Polymers. 2014, 112, 695–700.  

  31. Zijie Zhang, Frank Vriesekoop, Qipeng Yuan, Hao Liang. Effects of Nisin on the Antimicrobial Activity of D-limonene and its nanoemulsion.Food Chemistry. 2014, 150, 307-312.

  32. Yanan Li, Zijie Zhang, Qipeng Yuan, Hao Liang, Frank Vriesekoop. Process optimization and stability of D-limonene nanoemulsions prepared by catastrophic phase inversion method. Journal of Food Engineering.2013. 119(3), 419-424.

  33. Dan Song, Hao Liang, Pengqun Kuang, Pingwah Tang, Gaofei Hu, and Qipeng Yuan. Instability and Structural Change of 4-Methylsulfinyl-3-butenyl Isothiocyanate in the Hydrolytic Process. J. Agric. Food Chem., 2013, 61, 5097−5102.  

  34. Li Y, Liang H, Sun L, Wu J, Yuan Q. Nanoparticle-tethered NAD+ with in situ cofactor regeneration. Biotechnol Lett. 2013 35(6):915-919.  

  35. Hao Liang, Qipeng Yuan, Mingming Liu. Simultaneous Determination of Glucoraphanin and Sulforaphane in Brassica oleracea Seeds by High-Performance Liquid Chromatography with Evaporative Light-Scattering Detector. Natural Product Research. (SCI), 2013;27(2):194-197.

  36. Hao Liang and Qipeng Yuan. Natural sulforaphane as a functional chemopreventive agent – including a review of isolation, purification and analysis methods. Critical Reviews in Biotechnology.(SCI), 2012, 32(3):218-34.

  37. Hao Liang, Qipeng Yuan, Frank Vriesekoop, Fei Lv. Effects of Cyclodextrins on the Antimicrobial Activity of Plant-Derived Essential Oil Compounds. Food Chemistry. (SCI) 2012135(3), 1020-1027.  

  38. Liwei Sun, Hao Liang, Qipeng Yuan, Tianxin Wang, Hongchao Zhang. Study on a carboxyl-activated carrier and its properties for papain immobilization. Journal of Chemical Technology and Biotechnology. (SCI), 2012, 87(8),1083-1088.  

  39. Fei Lv, Hao Liang, Qipeng Yuan, Chunfang Li. In vitro antimicrobial effects and mechanism of action of selected plant essential oil combinations against four food-related microorganisms. Food Research International. (SCI), 2011, 44(9): 3057-3064.  


Address: Room W310, Science and Technology Building, Beijing University of ChemicalTechnology