Title: Alzheimer's Disease and Its Progress
Speaker: Professor Jianping Jia
Xuanwu Hospital, Capital Medical University
Time: 2:00–3:00 PM, Tuesday, January 13, 2026
Venue: Room 302, Science and Technology Building, East Campus
Speaker Biography
Professor Jia’s primary research focuses on dementia and Alzheimer’s disease (AD). He has published over 780 papers with more than 40,000 total citations, and has been ranked among the world’s highly cited scholars for 5 consecutive years. Among these, 342 SCI papers have been published in top international journals such as NEJM, Lancet, and BMJ, and he holds 18 authorized invention patents.
He has presided over more than 30 national and provincial-level research projects, including the formulation of 31 guidelines (such as the Chinese Guidelines for the Diagnosis and Management of Dementia) that have significantly standardized clinical dementia practice in China. He has led 36 high-level clinical trials of anti-dementia drugs for domestic and international pharmaceutical companies, designing multiple of these trials.
As the first corresponding author, he has won the Second Class Prize of the National Science and Technology Progress Award and the First Class Prize of the Beijing Science and Technology Progress Award. In 2021, he received the Zaven Khachaturian Award from the Alzheimer’s Association International Conference (AAIC), one of the highest honors in dementia research. He is the first Asian scholar to receive this award, and is recognized as the "Chief Architect of Clinical AD Research in China."
Report Abstract
Our team has identified novel genetic mutations in AD, revealing two new pathogenic mechanisms: palmitoylation modification of abnormal proteins and the interaction between Aβ oligomers and astrocytes, providing potential new targets for drug development.
For the first time, we have offered critical insights into the evolutionary trajectories of multiple pre-symptomatic AD biomarkers via the "AD dynamic biomarker cascade model," establishing key time windows for early prevention and precision intervention. These findings were published in The New England Journal of Medicine (NEJM).
Additionally, we conducted the first large-scale study in the Chinese population to demonstrate that six healthy lifestyle factors (including a reasonable diet, regular exercise, active social engagement, cognitive activity, smoking cessation, and limited alcohol consumption) can reduce the risk of dementia by up to 60%, providing the first high-level evidence for lifestyle interventions to prevent dementia in the Chinese population. This work was published in The BMJ.
Collectively, these studies have not only established an ultra-early diagnostic scheme for AD but also formed a precise prevention strategy covering the entire population, thereby building a full-cycle AD prevention and control system spanning from early screening to systematic intervention.
Organizer:
State Key Laboratory of Chemical Resource Engineering
School of Life Science and Technology, Beijing University of Chemical Technology
Professor Qiming Yuan’s Research Group
