Lin Baixue

Education:

September 2006–June 2010 Fujian Agriculture and Forestry University, Biochemistry and Molecular Biology, Ph.D.

September 2000–June 2003 South China University of Technology, Fermentation Engineering, Master’s Degree

September 1996–June 2000 South China University of Technology, Pharmaceutical Engineering (Minor in English), Bachelor’s Degree

Work Experience:

July 2025–Present Professor, School of Life Sciences and Technology, Beijing University of Chemical Technology

November 2021–June 2025 Research Fellow, Institute of Microbiology, Chinese Academy of Sciences

August 2016–November 2016 Visiting Scholar, University of Delaware

September 2015–October 2021 Associate Research Fellow, Institute of Microbiology, Chinese Academy of Sciences

April 2013–September 2015 Institute of Microbiology, Chinese Academy of Sciences, Assistant Researcher

September 2010–March 2013 Institute of Microbiology, Chinese Academy of Sciences, Postdoctoral Fellow

July 2003–September 2010 Fujian Agriculture and Forestry University, Assistant Researcher

Main Research Areas:

Metabolic Engineering and Synthetic Biology

The research group focuses on the construction and optimization of microbial cell factories, addressing key issues in biosynthetic processes. By integrating metabolic engineering and synthetic biology approaches, the group aims to enhance the synthetic efficiency of cell factories and achieve efficient, green biomanufacturing of high-value-added chemicals.

Academic Affiliations:

Reviewer for journals including *Metabolic Engineering*, *Chemical Engineering Journal*, *Journal of Agricultural and Food Chemistry*, *ACS Sustainable Chemistry & Engineering*, *Biotechnology and Bioengineering*, *Enzyme and Microbial Technology*, and *Synthetic and Systems Biotechnology*.

Academic Achievements:

Has led projects including a General Program grant from the National Natural Science Foundation of China, a sub-project under the National Key Research and Development Program, a Provincial Natural Science Foundation grant, a China Postdoctoral Science Foundation grant, and several major collaborative projects with industry partners.

Has published 34 SCI-indexed papers in leading international journals such as *Nature Communications*, *PNAS*, and *Metabolic Engineering*, and co-authored two monographs in Chinese and English. Has filed 28 national invention patent applications, with 18 granted; more than ten technological achievements have been transferred and commercialized.

Awards and Honors:

Second Prize, Science and Technology Progress Award, China National Light Industry Council

Top Ten Scientific Advances in Microbiology, Chinese Academy of Sciences

Distinguished Researcher, Chinese Academy of Sciences

Representative Publications:

[1]Hang Zhou, Yiwen Zhang, Christopher P. Long, Xuesen Xia, Yanfen Xue, Yanhe Ma*, Maciek R. Antoniewicz*, Yong Tao*, Baixue Lin*. A citric acid cycle-deficient Escherichia coli as an efficient chassis for aerobic fermentations. Nature Communications. 2024 ,15(1): 2372.

[2] Baixue Lin, Keqiang Fan, Jian Zhao, Junjie Ji, Linjun Wu, Keqian Yang*, Yong Tao*. Reconstitution of TCA cycle with DAOCS to engineer E. coli into an efficient whole cell catalyst of penicillin G. Proc Natl Acad Sci U S A 2015,112(32):9855-9

[3] Xiaojing Huo, Xuesen Xia, Nan Xue, Wei Peng, Yong Tao*, Baixue Lin*. Precursor balancing by reprogramming pyruvate synthesis for high-yield l-isoleucine production in engineered Escherichia coli. Bioresource Technology, 2026, 447:134270.

[4] Congrong Shi, Xiaojing Huo, Ran You, Yong Tao, Baixue Lin*. High yield production of L-isoleucine through readjusting the ratio of two direct precursors in Escherichia coli.Bioresource Technology. 2025, 418:131889.

[5] Hongzhong Du, Xiaofei Chen, Hongxiao Gong, Yudi Pang, Kai Yang, Zhiming Wang, Chong Gao, Baixue Lin, Zhiyuan He*. Bioinspired Anti‐Freezing Hydrogel With Localized Ice Regulation for Subzero Soft Robotics. Angewandte Chemie International Edition.2025, 64.64(41):e202512142.

[6] Qun Liu, Baixue Lin*, Yong Tao*. Improved methylation in E. coli via an efficient methyl supply system driven by betaine. Metabolic Engineering. 2022, 72: 46-55.

[7] Quanxiu Gao, Hao Chen, Gaoyan Wang, Wei Yang, Xiaotong Zhong, Jiezheng Liu, XiaoJing Huo, Weifeng Liu, Jianzhong Huang*, Yong Tao*, Baixue Lin*. Highly Efficient Production of Menaquinone 7 from Glucose by Metabolically Engineered Escherichia coli. ACS Synthetic Biology. 2021, 10(4): 756–765.

[8] Zhanhui Wang#, Baixue Lin#, Siyu Sheng, Sicong Tan, Pengchao Wang, Yong Tao, Zhang Liu, Zhiyuan He*,Jianjun Wang. Bioinspired Anti-Icing Hydrogel Enabled by Ice-Nucleating Protein. CCS Chem. 2021, 3:473–480.

[9]Yiwen Zhang, Hang Zhou, Yong Tao*, Baixue Lin*. Reconstitution of the Ornithine Cycle with Arginine:Glycine Amidinotransferase to Engineer Escherichia coli into an Efficient Whole-Cell Catalyst of Guanidinoacetate. ACS Synthetic Biology. 2020,9(8):2066-2075.

[10] Jiangming Zhu, Wei Yang, Bohua Wang, Qun Liu, Xiaotong Zhong, Quanxiu Gao, Jiezheng Liu, Jianzhong Huang*, Baixue Lin*, Yong Tao. Metabolic engineering of Escherichia coli for efficient production of L-alanyl-L-glutamine. Microbial Cell Factories.2020,19(1):129.

[11] Jing Feng, Ruifeng Li, Shasha Zhang, Yifan Bu, Yanchun Chen, Yinglu Cui, Baixue Lin, Yihua Chen, Yong Tao, Bian Wu*. Bioretrosynthesis of Functionalized N-Heterocycles from Glucose via One-Pot Tandem Collaborations of Designed Microbes. Advanced Science, 2020, 7(17): 2001188.

[12] Quanxiu Gao, Hao Chen, Wenzhao Wang, Jianzhong Huang, Yong Tao, Baixue Lin*. Menaquinone-7 production in engineered Escherichia coli. World Journal of Microbiology and Biotechnology.2020, 36:132.

[13] Xiaoyu Piao, Lei Wang, Baixue Lin, Hao Chen, Weifeng Liu*, Tao Yong*. Metabolic engineering of Escherichia coli for production of L-aspartate and its derivative beta-alanine with high stoichiometric yield. Metabolic engineering. 2019, 54:244-254

[14] Shasha Zhang, Wei Yang, Hao Chen, Bo Liu, Baixue Lin*, Yong Tao*. Metabolic engineering for efficient supply of acetyl-CoA from different carbon sources in Escherichia coli. Microbial Cell Factories. 2019,18:130.

[15] Pengchao Wang, Xinwei Yang, Baixue Lin*, Jianzhong Huang*, Yong Tao*. Cofactor self-sufficient whole-cell biocatalysts for the production of 2-phenylethanol. Metabolic Engineering, 2017,44:143-149.

[16] Baixue Lin*, Yong Tao*. Whole-cell biocatalysts by design. Microbial Cell Factories, 2017, 16:106.

[17] Xun Lv, Hongzhi Cao, Baixue Lin*, Wei Wang, Wande Zhang, Qian Duan, Yong Tao, Xue-Wei Liu, Xuebing Li*. Synthesis of sialic acids, their derivatives and analogues using a whole-cell catalyst. Chemistry - A European Journal, 2017,23(26): 15143–15149.

[18] Baixue Lin*, Yu Qiao, Bo Shi, Yong Tao. Polysialic acid biosynthesis and production in Escherichia coli: Current state and perspectives. Applied Microbiology and Biotechnology, 2016,100(1):1-8.

[19] Keqiang Fan, Baixue Lin, Yong Tao, Keqian Yang*. Engineering deacetoxycephalosporin C synthase as a catalyst for the bioconversion of penicillins. Journal of Industrial Microbiology & Biotechnology. 2016,44(4): 705-710.

[20] Fang Chen, Yong Tao, Cheng Jin, Yang Xu, Baixue Lin*. Enhanced production of polysialic acid by metabolic engineering of Escherichia coli. Applied Microbiology and Biotechnology, 2015,99:2603-2611.

[21] Baixue Lin, Zijuan Zhang, Weifeng Liu, Zhiyang Dong, Yong Tao*. Enhanced production of N-acetyl-D-neuraminic acid by multi-approach whole-cell biocatalyst. Applied Microbiology and Biotechnology, 2013,97: 4775-84.

Message from the Faculty:

Be your personal best — strive to be the best version of yourself, and continue to grow and excel in both research and life.

Admission Requirements:

A passion for research, diligence, and a thoughtful mindset.