Academic Report
Time:14:00, Wednesday, September 16, 2026
Location:Conference Room 702, High-Tech Building
Speaker:Wang Yugang, Tongji School of Basic Medical Sciences, Huazhong University of Science and Technology
Speaker Profile:
Wang Yugang, Level 3 Professor, doctoral supervisor, selected for the National High-Level Talent Program, Vice Dean of Tongji Basic Medical College at Huazhong University of Science and Technology, Deputy Director of the Cell Architecture Research Center (CARC) at Huazhong University of Science and Technology, Academic Key Investigator (PI) of the National Key Laboratory for Severe Diagnosis and Treatment of Zoonotic Infectious Diseases, Vice Chairman of the Hubei Society for Biochemistry and Molecular Biology. His research focuses on novel types, mechanisms, and functions of histone modifications, exploring the unknown laws governing the storage and expression of genetic information in important physiological and pathophysiological processes. His major academic achievements have been published in journals such as Nature, Nature Chemical Biology, Cell Reports Medicine, and Science Advances, and he received the Longest Sulfation Pathway Award from the British Biochemical Society. He has led a key project of the Ministry of Science and Technology's Young Scientist Program and several National Natural Science Foundation of China projects. He is the chief editor of the Fourteenth Five-Year Plan textbook for postgraduate education published by Science Press, Medical Biochemistry and Molecular Biology.
Report Abstract：
Histone post-translational modifications are a core mechanism for the storage and regulation of genetic information in eukaryotic cells. Although more than 30 types of histone modifications are currently known, the complex regulatory mechanisms and patterns of chromatin function remain difficult to explain. Tyrosine sulfation is a novel type of histone post-translational modification discovered by our research group in recent years. This report will systematically introduce the regulatory, catalytic, and downstream functional mechanisms of histone sulfation modifications in mammalian cells, elucidate the currently known physiological and pathological functions of this modification, and explore future research directions and clinical applications of histone sulfation modification theory.
Feng Yue Research Group, College of Life Science and Technology
